We are developing a Point-of-Care GMP-compliant chemistry lab (MT-100) that combines the production of [O-15]-H2O with the infusion of the tracer into the patient – in one automated process. Connected to a cyclotron, the MT-100 converts the O-15 gas to [O-15]-H2O. A unique injection system delivers the tracer to the patient via a venflon.

Design vision

The MT-100 is about the size of a medium refrigiator, with a height of app. 60 in/150 cm. It weighs app 1,300 lbs/600 kg due to the lead shielding. Jeg sender fotos som du kan arbejde videre med som side illustration.

How it works

A full patient procedure consisting of a rest and stress scan with two injections can be completed within 30 minutes. With the short half-life of [O-15] of only 122 seconds, the patient can stay on the scanner bed while the initial injection decays awaiting the second scan.

The MT-100 (A) is placed next to a PET-CT scanner (B) and connected to an onsite cyclotron (C). Both proton (p,n) and deuteron (d,n) cyclotrons are applicable. The cyclotron can be placed up to 1,600 feet/500 meters away from the PET scanner.

1)Once the patient and the PET scanner are ready, the MT-100 will call for [O-15] O2 gas from the connected cyclotron.
2)The MT-100 will convert the [O-15] O2 gas into [O-15] H2O under GMP conditions, prepare the desired dose, and inject it into the patient in one automated process.
3)For cardiology, the procedure is repeated after a stress agent is injected. Due to the short half-life of [O-15]-H2O, the repeat scan can start only 10 minutes after the initial scan has started
4)Once the scan procedure is completed, the doctors can diagnose the patient using the aQuant analytical software (D), and compare the myocardial blood flow at rest and under stress conditions. Read more about aQuant here